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KMID : 0361020000430040387
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 4 p.387 ~ p.390
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Clinical Value of Eosinophil Cationic Protein Level in Nasal Secretion of Allergic Rhinitis Patients
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Shin Seung-Heon
Jeon Byeong-Gyu
Heo Won-Wook
Lee Young-Ho
Ye Mi-Kyung
Sohn Jin-Ho
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Abstract
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Background and Objectives : Eosinophil cationic protein (ECP) is one of the major granule-derived
proteins with cytotoxic activity derived from eosinophils. It has also been used as a marker of allergic
inflammation. In this study, we measured ECP levels in nasal secretion to evaluate its effect on nasal
allergic symptoms.
Materials and Methods : ECP was measured in nasal secretion and in serum of 30 symptomatic allergic
rhinitis patients, 20 non-allergic rhinitis patients, and 15 normal controls. We also measured symptom
scores composed on sneezing, itching, rhinorrhea, nasal obstruction, and nasal blowing.
Results : The ECP level in the nasal secretion of allergic rhinitis was higher than those of non-allergic
rhinitis and the normal control (p<0.001). The difference of ECP levels in serum among three groups
didn’t have statistical significance, but there was statistically significant correlation between the ECP level
in nasal secretion and the mean symptom scores in allergic rhinitis (p=0.006).
Conclusion : The ECP level in nasal secretions seems to be a very useful parameter for monitoring and
assessing the condition of nasal allergic inflammation in allergic rhinitis.
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KEYWORD
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Allergic rhinitis, Eosinophil cationic protein, Symptom score
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